Auvelity Side Effects: What to Expect and How to Manage Them Effectively

Starting a new antidepressant like Auvelity can feel like a huge step—especially when you’re already navigating the ups and downs of major depressive disorder (MDD). While this innovative medication has shown promising results for many, it’s crucial to understand the potential side effects, how to manage them, and when to seek help.

Auvelity (a combination of dextromethorphan and bupropion) is designed as an extended-release oral tablet that works uniquely to improve symptoms of depression in adults. Its formulation allows for a steady release of medication throughout the day, which helps many patients feel more stable over time. Still, like all antidepressants, it comes with a learning curve—your body needs time to adjust, and certain side effects might crop up along the way.

This comprehensive guide will walk you through everything you need to know about Auvelity side effects, offering real-life tips, expert-backed advice, and reassurance as you begin your treatment journey.

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What is Auvelity and Why Do Side Effects Occur?

Auvelity stands out among antidepressants thanks to its dual-action formula. Dextromethorphan works on the NMDA receptor (a brain receptor involved in mood and cognition), while bupropion boosts dopamine and norepinephrine, two feel-good brain chemicals. The combination is thought to provide faster relief than traditional antidepressants.

However, since this medication targets multiple brain pathways, it can also lead to a variety of side effects—especially during the first few weeks.

Understanding these effects isn’t about scaring you—it’s about helping you feel more in control and giving you the tools to manage them confidently.

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Common Side Effects of Auvelity

Most patients will experience mild to moderate side effects, especially early on. These symptoms often improve within the first few weeks as your body adapts to the medication.

Most Frequently Reported Symptoms

According to clinical trials and patient reports, the following are the most common side effects:

• Headache
• Dizziness
• Diarrhea
• Fatigue or drowsiness
• Dry mouth
• Excessive sweating
• Sexual dysfunction (low libido or performance issues)

Other side effects some people experience include:

• Nausea
• Constipation
• Insomnia
• Blurred vision
• Loss of appetite
• Tingling or numbness in hands, feet, arms, or legs
• Joint or muscle discomfort

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At-Home Management Tips for Common Symptoms

Many mild side effects can be managed without stopping the medication. Here are practical tips to help you feel more comfortable:

Dry Mouth

• Sip water throughout the day.
• Chew sugar-free gum or suck on lozenges to boost saliva.
• Avoid caffeine and alcohol—they make dry mouth worse.
• Switch to alcohol-free mouthwash.

Digestive Upset (Diarrhea or Constipation)

• For diarrhea: Stick to bland foods (rice, toast, bananas). Stay hydrated.
• For constipation: Eat fiber-rich foods (fruits, veggies, whole grains), drink plenty of fluids, and consider a stool softener if needed.

Dizziness

• Rise slowly when getting out of bed or standing up.
• Avoid driving or using heavy machinery until the dizziness passes.
• Stay hydrated and avoid alcohol.

Nausea

• Try taking Auvelity with food (check with your doctor first).
• Eat smaller, more frequent meals.
• Sip ginger tea or try ginger supplements.

Sweating

• Wear breathable clothing and layers you can easily remove.
• Use clinical-strength antiperspirants with aluminum chloride.
• Stay cool—carry a hand fan or water mist if needed.

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Serious Side Effects: Know the Warning Signs

While rare, serious side effects can occur and require immediate attention.

1. Seizures

• Bupropion, one of the ingredients in Auvelity, may increase seizure risk.
• Especially risky for people with eating disorders, epilepsy, or heavy alcohol use.
• Warning signs include twitching, loss of consciousness, or staring spells.
• If you or someone near you experiences these symptoms, call emergency services immediately.

2. Suicidal Thoughts or Behavior

• Auvelity carries an FDA boxed warning about increased risk of suicidal ideation in adults under 25.
• Risk is highest during the first few months of treatment or after a dosage change.
• Watch for:
  • Agitation or irritability
  • Withdrawal from friends/family
  • Unusual mood swings
  • Thoughts or talk of self-harm

If you’re in crisis, call 911 or the Suicide & Crisis Lifeline at 988 (text or call).

3. Elevated Blood Pressure

• Auvelity may raise your blood pressure.
• Regular monitoring is key, especially if you already have hypertension.
• Let your doctor know if you notice headaches, chest pain, or blurry vision.

4. Psychosis or Manic Episodes

• In rare cases, users may experience hallucinations, paranoia, or mania (especially if undiagnosed bipolar disorder is present).
• Symptoms may include racing thoughts, risky behavior, or excessive energy.
• Auvelity is not recommended for individuals with bipolar disorder.

5. Allergic Reactions

• Though uncommon, watch for:
  • Skin rash
  • Facial swelling
  • Hives
  • Difficulty breathing

Seek emergency care if you suspect an allergic reaction.

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Healthy Lifestyle Strategies to Reduce Side Effects

1. Nutritional Support

• Eat a balanced diet rich in brain-boosting nutrients:
  • Omega-3s (salmon, walnuts)
  • Complex carbs (brown rice, lentils)
  • Leafy greens and berries (antioxidants)
• Keep meal timing consistent.
• Avoid sugar spikes, which can crash your mood and energy levels.

2. Exercise

• Gentle activity improves circulation, reduces stress, and eases fatigue.
• Start with 20–30 minutes of walking, stretching, or yoga.
• Listen to your body—exercise should energize you, not drain you.

3. Better Sleep Habits

• Stick to a consistent bedtime.
• Create a relaxing wind-down routine (read, meditate, avoid screens).
• Keep your room cool, dark, and quiet.
• Limit caffeine in the afternoon.

If insomnia continues, speak to your doctor about adjusting your dose timing.

4. Stress Management

• Daily stress can amplify side effects.
• Try deep breathing, journaling, meditation, or nature walks.
• Avoid multitasking and schedule “unplug” time daily.

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Talking to Your Doctor: Why It Matters

When to Speak Up

Don’t wait until your next check-up if something feels off. Contact your provider if:

• Side effects last more than 2–3 weeks
• Symptoms worsen over time
• They interfere with your daily activities
• You experience any serious side effects listed above

How to Prepare for Your Appointments

• Keep a symptom journal: What are you feeling? When do symptoms occur?
• Note any patterns: Are certain foods, times of day, or activities making symptoms worse?
• Write down questions or concerns in advance.

Possible Adjustments

Your provider might:

• Adjust the dosage
• Change the time you take your medication
• Add a second medication to offset side effects
• Recommend switching to another antidepressant

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Weighing the Risks and Benefits of Auvelity

Let’s be clear: No treatment is side effect–free. But when you’re living with depression, the benefits of finding the right medication can far outweigh the temporary discomforts of adjustment.

Auvelity offers a promising path—especially for individuals who haven’t responded well to other antidepressants. With guidance from your doctor and a clear side effect management plan, many users report significant improvements in mood, motivation, and overall well-being.

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Final Thoughts

Starting Auvelity may come with challenges, but it’s also a step toward healing. Stay patient, stay informed, and stay connected with your care team. Most side effects will diminish over time—and as they do, your mental clarity and emotional balance may improve in ways you didn’t think possible.

You’re not alone in this journey. Keep communicating with your healthcare provider, and don’t hesitate to ask questions or speak up if something doesn’t feel right. With proper management and support, many people find that Auvelity becomes a valuable tool in their recovery from depression.