Myfembree Side Effects and How to Manage Them Safely

Starting a new medication often brings a mix of relief and uncertainty. On one hand, there’s hope—hope that the treatment will finally bring relief from symptoms that interfere with daily life. On the other hand, there are questions: What side effects might I face? How will my body react? Will I be able to manage them without too much disruption?

For many women living with uterine fibroids, these questions come up when prescribed Myfembree. This medication has offered a breakthrough in managing heavy menstrual bleeding and painful fibroid-related symptoms. However, like any prescription drug, Myfembree comes with its own set of possible side effects.

Being informed doesn’t mean you should avoid treatment—it means you’ll know what to expect, when to call your doctor, and how to take practical steps to stay in control of your health. This guide provides an in-depth look at both the common and serious side effects of Myfembree, along with actionable strategies for managing them.

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What Is Myfembree and How Does It Work?

Myfembree is a prescription medication specifically approved to treat heavy menstrual bleeding caused by uterine fibroids in premenopausal women. Fibroids are noncancerous growths in the uterus that can lead to a host of problems: prolonged bleeding, severe cramps, pelvic pressure, and even fertility challenges.

For many women, fibroids are more than a medical condition—they affect work, social life, relationships, and emotional well-being. Traditional options like surgery or invasive procedures are not always desirable or possible. That’s where Myfembree offers an alternative.

The Science Behind Myfembree

Myfembree is a combination therapy that includes three active ingredients:

1. Relugolix – a gonadotropin-releasing hormone (GnRH) antagonist that reduces the body’s estrogen production.
2. Estradiol – a form of estrogen that helps balance hormone levels to reduce extreme side effects of low estrogen.
3. Norethindrone acetate – a progestin that protects bone density and stabilizes the endometrium (lining of the uterus).

Together, these ingredients work in harmony to create a “hormone-balancing act.” They lower estrogen levels enough to shrink fibroid symptoms but add back small amounts of estrogen and progestin to reduce risks like bone loss and severe menopausal symptoms.

How Effective Is It?

In clinical studies, including one published in the New England Journal of Medicine, Myfembree significantly reduced heavy menstrual bleeding in women with fibroids. Many patients reported lighter, shorter periods—or, in some cases, no bleeding at all. This can feel life-changing for women who previously struggled to manage daily routines around excessive bleeding.

But while the benefits are substantial, the treatment journey comes with potential challenges, particularly when it comes to side effects.

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Common Side Effects of Myfembree

Like most medications that alter hormone levels, Myfembree can cause mild to moderate side effects. These are usually temporary and may improve as your body adapts to the medication over time.

What You May Experience

Some of the most frequently reported side effects include:

• Hot flashes – sudden waves of warmth, flushing of the face, and sweating. Roughly 70% of women taking Myfembree report hot flashes.
• Night sweats and increased sweating – often linked to hot flashes, these can disrupt sleep.
• Hair loss or thinning – mild hair shedding may occur due to hormone changes.
• Changes in menstrual cycle – lighter periods, shorter cycles, or missed periods altogether.
• Low libido – a reduction in sexual desire is common during hormone-related treatments.
• Headaches – mild to moderate headaches may develop, especially in the first few weeks.
• Nausea – queasiness that sometimes improves when medication is taken with food.
• Fatigue – feeling unusually tired or drained.
• Joint or back pain – some patients report aches that resemble mild arthritis.

Why These Side Effects Happen

Most of these side effects are tied to hormonal fluctuations. When estrogen levels drop—even partially—the body reacts in ways that resemble menopause. Hot flashes, mood changes, and lower libido are classic signs of reduced estrogen.

The good news? For many women, these side effects become less intense after the first few weeks of treatment. But if they persist or significantly interfere with daily life, it’s worth discussing with your doctor.

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Serious Side Effects You Shouldn’t Ignore

While uncommon, Myfembree does carry risks of serious side effects. These require immediate medical attention.

Blood Clots and Cardiovascular Risks

Myfembree carries an FDA boxed warning—the strongest type of medication warning—because it may increase the risk of:

• Deep vein thrombosis (DVT) – blood clots forming in the legs.
• Pulmonary embolism (PE) – clots that travel to the lungs.
• Heart attack or stroke – due to blood vessel blockage.

These risks are highest in women over 35 who smoke or those with high blood pressure, obesity, or a history of heart disease.

⚠️ Seek emergency care immediately if you notice:

• Pain, swelling, or warmth in your arm or leg
• Sudden shortness of breath
• Sharp chest pain
• Dizziness or fainting

Other Serious Risks

• High Blood Pressure – can lead to headaches, dizziness, or nosebleeds.
• Bone Density Loss – long-term use (over 24 months) may increase risk of osteoporosis.
• Mood Disorders – depression, anxiety, or suicidal thoughts.
• Liver and Gallbladder Problems – symptoms may include upper right abdominal pain, dark urine, or jaundice.
• High Blood Sugar – leading to excessive thirst and frequent urination.
• Increased Cholesterol/Triglycerides – which raises cardiovascular risks.
• Fibroid Prolapse or Expulsion – fibroids may pass through the vagina, causing cramping and bleeding.
• Severe Allergic Reactions – rash, swelling of the face/lips/throat, or difficulty breathing.

These aren’t side effects to “wait out.” If they appear, call your doctor immediately or seek emergency help.

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Why Monitoring Matters

Because Myfembree can affect multiple body systems, regular monitoring is key. Your doctor may recommend:

• Blood pressure checks – to catch early signs of hypertension.
• Bone density scans – especially if treatment extends beyond one year.
• Mental health check-ins – to monitor mood changes.
• Blood tests – to track liver function, blood sugar, and cholesterol levels.

Think of these checkups as safety nets—they help catch problems early before they escalate.

Practical Tips for Managing Myfembree Side Effects

Living with side effects can feel overwhelming at first, but most women find ways to adapt. The goal isn’t just to “tough it out”—it’s to take proactive steps that reduce discomfort and support overall health while on treatment.

Here’s how you can manage the most common side effects of Myfembree:

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🌡️ Managing Hot Flashes and Night Sweats

Hot flashes are one of the most common complaints for women taking Myfembree. They may strike during the day or disrupt sleep at night. While you can’t eliminate them entirely, small lifestyle adjustments make a big difference.

✅ What Helps:

• Dress in lightweight, layered clothing that you can remove easily.
• Sleep with cotton sheets and breathable pajamas to reduce overheating.
• Keep a fan by your bed or lower your thermostat at night.
• Identify and avoid triggers like alcohol, caffeine, and spicy foods.
• Stay hydrated with cool water throughout the day.

Many women also find relief with guided relaxation techniques, such as slow breathing or meditation during a hot flash episode.

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🤢 Easing Nausea

Nausea can occur during the first weeks of treatment as your body adjusts.

✅ What Helps:

• Take Myfembree with food or a glass of milk.
• Eat smaller, frequent meals instead of large portions.
• Choose bland, easy-to-digest foods like rice, toast, or bananas.
• Try ginger tea, ginger chews, or peppermint—all natural nausea soothers.
• Avoid lying down immediately after eating.

If nausea persists, ask your doctor whether an anti-nausea medication might be appropriate.

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💇 Coping with Hair Loss or Thinning

Hormonal changes can sometimes lead to mild hair shedding. While this can feel distressing, it’s usually temporary.

✅ What Helps:

• Use gentle, sulfate-free shampoos to avoid scalp irritation.
• Limit heat styling and harsh chemical treatments.
• Choose wide-tooth combs to reduce breakage.
• Eat a nutrient-rich diet with biotin, zinc, and iron to support hair growth.
• Ask your doctor if supplements may help, but always confirm before starting any new product.

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🛌 Beating Fatigue

Low energy levels are another commonly reported side effect.

✅ What Helps:

• Prioritize consistent sleep habits—aim for 7–9 hours nightly.
• Engage in light physical activity, such as walking or yoga, to boost energy.
• Avoid excess caffeine, which can disrupt sleep later.
• Break up large tasks into smaller, manageable steps.

Sometimes, fatigue is worsened by anemia from heavy bleeding. If you’re still bleeding heavily while on Myfembree, ask your doctor about checking your iron levels.

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💔 Addressing Mood Changes

Hormonal fluctuations can influence mood. Some women report increased irritability, sadness, or anxiety while on Myfembree.

✅ What Helps:

• Incorporate stress-reducing practices: yoga, meditation, journaling, or deep breathing.
• Maintain regular exercise—even short walks release endorphins.
• Stay connected with friends and loved ones for emotional support.
• Avoid excess alcohol and caffeine, which can worsen mood swings.
• If symptoms intensify, talk openly with your healthcare provider.

⚠️ Important: If you ever experience severe depression or suicidal thoughts, seek immediate help by contacting the 988 Suicide & Crisis Lifeline or your local emergency number.

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When to Call Your Doctor

Not all side effects require medical intervention—but some absolutely do. Open, ongoing communication with your doctor is essential.

📞 Call your doctor if:

• Mild side effects last longer than a few weeks or significantly disrupt daily life.
• You notice severe headaches, chest pain, or leg swelling.
• Your mood changes feel overwhelming or include suicidal thoughts.
• You experience yellowing of the skin/eyes, dark urine, or abdominal pain (possible liver issues).
• You become pregnant or plan to become pregnant—Myfembree is unsafe in pregnancy.

As Dr. Emily Carter, a women’s health specialist, explains:

“Managing uterine fibroids isn’t just about reducing bleeding—it’s about balancing benefits with risks. The key is partnership. Patients who communicate openly with their providers have the best outcomes.”

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The Importance of Personalized Care

No two women experience Myfembree in exactly the same way. For some, side effects are barely noticeable. For others, they can feel more intense. That’s why treatment works best when it’s tailored to your body, your symptoms, and your lifestyle.

Your doctor may adjust your treatment plan if:

• Side effects become unmanageable.
• You have underlying conditions (e.g., hypertension, diabetes, mood disorders).
• You’re considering pregnancy in the near future.
• You need alternative therapies to supplement or replace Myfembree.

Sometimes, the solution is as simple as shortening the length of treatment or switching to a different fibroid management approach.

Conclusion: Balancing Benefits and Side Effects

Starting Myfembree is often a turning point for women living with uterine fibroids and heavy menstrual bleeding. For many, the medication brings a sense of relief—lighter cycles, less pain, and the ability to live more fully without being sidelined by their symptoms. But as with any treatment, the benefits come alongside potential risks and side effects.

The most important takeaway is this: side effects are not a sign of failure—they’re a signal. They’re your body’s way of communicating how it’s responding to the medication. Some may fade as your system adjusts, while others may require active management or medical intervention.

The common side effects—like hot flashes, nausea, fatigue, and hair thinning—are usually manageable with lifestyle adjustments, simple remedies, or guidance from your healthcare provider. On the other hand, the serious risks—such as blood clots, liver problems, bone density loss, and mood changes—demand closer monitoring and prompt communication with your doctor.

Long-term safety is also key. Because Myfembree can affect bone health, treatment is generally limited to 24 months. This makes it even more important to view Myfembree as one step in a larger fibroid management plan, rather than a lifelong solution.

Ultimately, the decision to continue or adjust your Myfembree treatment should always be based on an honest conversation between you and your doctor. As women’s health expert Dr. Jane Smith explains:

“The right treatment balances symptom relief with long-term safety. What works beautifully for one patient may not be ideal for another—that’s why personalized care matters.”

Your health journey is a partnership. By staying informed, paying attention to your body, and speaking up when something feels off, you give yourself the best chance to maximize the benefits of Myfembree while minimizing its risks.

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Frequently Asked Questions (FAQs)

1. How long does it take for Myfembree side effects to appear?

Most side effects show up in the first few weeks as your body adjusts to hormonal changes. Hot flashes and nausea tend to appear early, while bone density changes occur over time.

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2. Can I take vitamins or supplements with Myfembree to reduce side effects?

Yes, but always check with your doctor first. Supplements like calcium, vitamin D, and iron may help support bone health and energy levels, but your provider should confirm the right dosage for your needs.

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3. Will side effects go away after I stop taking Myfembree?

In many cases, yes. Common side effects like hot flashes, headaches, or low libido often improve after stopping the medication. However, long-term effects like bone density loss may take longer to recover—or may not fully reverse—so ongoing monitoring is essential.

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4. Is Myfembree safe if I want to get pregnant in the future?

Yes, but only after you stop taking it. Myfembree is not safe to use during pregnancy and may cause early pregnancy loss. Most women regain their normal cycles after discontinuation, but you should always talk to your doctor before trying to conceive.

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5. Are there alternatives if I can’t tolerate Myfembree?

Absolutely. Other treatment options for fibroids include:

• Hormonal IUDs (which may lighten bleeding)
• GnRH agonists or antagonists (other hormonal therapies)
• Minimally invasive procedures like uterine artery embolization
• Surgery (myomectomy or hysterectomy, depending on your situation)

Your doctor can help you decide which alternative best fits your symptoms, medical history, and future fertility plans.

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Final Thoughts

Myfembree offers a promising path for women struggling with fibroids, but it isn’t a one-size-fits-all solution. Side effects range from mild nuisances to potentially serious health concerns, and knowing how to manage them is part of making this treatment work for you.

Think of your health as a team effort:

• You bring awareness and self-advocacy.
• Your doctor brings expertise and medical oversight.
• Together, you can shape a plan that relieves fibroid symptoms while protecting your overall well-being.

By staying informed, listening to your body, and keeping an open dialogue with your healthcare provider, you put yourself in the best position to thrive—not just survive—while managing uterine fibroids.